Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Subthalamic GAD gene therapy in a Parkinson's disease rat model.

Science (New York, N.Y.) - 11 Oct 2002

Luo Jia, Kaplitt Michael G, Fitzsimons Helen L, Zuzga David S, Liu Yuhong, Oshinsky Michael L, During Matthew J

Abstract excerpt

The motor abnormalities of Parkinson's disease (PD) are caused by alterations in basal ganglia network activity, including disinhibition of the subthalamic nucleus (STN), and excessive activity of the major output nuclei. Using adeno-associated viral vector-mediated somatic cell gene transfer, we expressed glutamic acid decarboxylase (GAD), the enzyme that catalyzes synthesis of the neurotransmitter GABA, in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dependovirus
Share to Electric Stimulation
Share to gamma-Aminobutyric Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutamate Decarboxylase

Share to Mesencephalon

Share to Oxidopamine

Share to Parkinsonian Disorders

Share to Substantia Nigra

Source

Identifiers

PMID: 12376704
DOI: 10.1126/science.1074549

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Subthalamic GAD gene therapy in a Parkinson's disease rat model.PMID 12376704Read ↗

A compact glutamic acid decarboxylase 67 promoter enables inhibitory neuron-targeted AAV gene therapy for treatment-resistant epilepsySemantic proximity Read ↗

Long-term follow-up of a randomized AAV2-GAD gene therapy trial for Parkinson’s diseaseSemantic proximity Read ↗

Knockdown of GAD67 protein levels normalizes neuronal activity in a rat model of Parkinson's diseaseSemantic proximity Read ↗

Gene therapy for Parkinson's diseaseSemantic proximity Read ↗

Functional Analysis of Distinct Populations of Subthalamic Nucleus Neurons on Parkinson’s Disease and OCD-like Behaviors in MiceSemantic proximity Read ↗

High-frequency stimulation of the subthalamic nucleus induces a sustained inhibition of serotonergic system via loss of cell phenotype.Semantic proximity Read ↗

Chronic High-frequency Stimulation of the Subthalamic Nucleus Induces a Sustained Inhibition of Serotonergic System via Loss of Cell PhenotypeSemantic proximity Read ↗

Chemogenetic restoration of autonomous subthalamic nucleus activity ameliorates Parkinsonian motor dysfunctionSemantic proximity Read ↗

Perspective on the Road toward Gene Therapy for Parkinson’s DiseaseSemantic proximity Read ↗

To serve and protect? Interventions in the subthalamic nucleus for Parkinson's disease. Commentary on "Ablation of the subthalamic nucleus protects dopaminergic phenotype but not cell survival in a rat model of Parkinson's disease".Semantic proximity Read ↗

Immunotoxin-Mediated Tract Targeting in the Primate Brain: Selective Elimination of the Cortico-Subthalamic “Hyperdirect” PathwaySemantic proximity Read ↗

Subthalamic nucleus deep brain stimulation is neuroprotective in the A53T α-synuclein Parkinson's disease rat model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.