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Article

Genetic Architecture and Clinical Outcomes of Combined Lipid Disturbances.

Circulation research - 5 Jul 2024

Gilliland Thomas, Dron Jacqueline S, Selvaraj Margaret Sunitha, Trinder Mark, Paruchuri Kaavya, Urbut Sarah M, Haidermota Sara, Bernardo Rachel, Uddin Md Mesbah, Honigberg Michael C, Peloso Gina M, Natarajan Pradeep

Abstract excerpt

BACKGROUND: Dyslipoproteinemia often involves simultaneous derangements of multiple lipid traits. We aimed to evaluate the phenotypic and genetic characteristics of combined lipid disturbances in a general population-based cohort. METHODS: Among UK Biobank participants without prevalent coronary artery disease, we used blood lipid and apolipoprotein B concentrations to ascribe individuals into 1 of 6 reproducible...

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Identifiers

PMID: 38828614
DOI: 10.1161/CIRCRESAHA.123.323973
PMCID: PMC11223949

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