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Article

Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding.

Proceedings of the National Academy of Sciences of the United States of America - 24 Feb 2015

Wang GuoZhen, Fersht Alan R

Abstract excerpt

Destabilized mutant p53s coaggregate with WT p53, p63, and p73 in cancer cell lines. We found that stoichiometric amounts of aggregation-prone mutants induced only small amounts of WT p53 to coaggregate, and preformed aggregates did not significantly seed the aggregation of bulk protein. Similarly, p53 mutants trapped only small amounts of p63 and p73 into their p53 aggregates. Tetrameric full-length protein...

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Identifiers

PMID: 25675527
DOI: 10.1073/pnas.1500262112
PMCID: PMC4345553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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