Non-genetic cell-to-cell variability and the consequences for pharmacology.

Abstract excerpt

Recent advances in single-cell assays have focused attention on the fact that even members of a genetically identical group of cells or organisms in identical environments can exhibit variability in drug sensitivity, cellular response, and phenotype. Underlying much of this variability is stochasticity in gene expression, which can produce unique proteomes even in genetically identical cells. Here we discuss the...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cells
• Share to Drug Therapy
• Share to Organ Specificity