Article
Single-cell phenomics reveals intra-species variation of phenotypic noise in yeast.
BMC systems biology - 3 Jul 2013
Yvert Gaël, Ohnuki Shinsuke, Nogami Satoru, Imanaga Yasutaka, Fehrmann Steffen, Schacherer Joseph, Ohya Yoshikazu
Abstract excerpt
BACKGROUND: Most quantitative measures of phenotypic traits represent macroscopic contributions of large numbers of cells. Yet, cells of a tissue do not behave similarly, and molecular studies on several organisms have shown that regulations can be highly stochastic, sometimes generating diversified cellular phenotypes within tissues. Phenotypic noise, defined here as trait variability among isogenic cells of the...
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