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Article

Protein kinase C zeta regulates human pancreatic cancer cell transformed growth and invasion through a STAT3-dependent mechanism.

PloS one - 1 Jan 2013

Butler Amanda M, Scotti Buzhardt Michele L, Li Shuhua, Smith Kristin E, Fields Alan P, Murray Nicole R

Abstract excerpt

Pancreatic cancer is a very aggressive disease with few therapeutic options. In this study, we investigate the role of protein kinase C zeta (PKCζ) in pancreatic cancer cells. PKCζ has been shown to act as either a tumor suppressor or tumor promoter depending upon the cellular context. We find th...

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Source

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Identifiers

PMID: 24015205
DOI: 10.1371/journal.pone.0072061
PMCID: PMC3756013

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24015205-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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