Article
A splice variant of RILP induces lysosomal clustering independent of dynein recruitment.
Biochemical and biophysical research communications - 9 Jun 2006
Marsman Marije, Jordens Ingrid, Rocha Nuno, Kuijl Coenraad, Janssen Lennert, Neefjes Jacques
Abstract excerpt
The small GTPase Rab7 controls fusion and transport of late endocytic compartments. A critical mediator is the Rab7 effector RILP that recruits the minus-end dynein-dynactin motor complex to these compartments. We identified a natural occurring splice variant of RILP (RILPsv) lacking only 27 amino acids encoded by exon VII. Both variants bind Rab7, prolong its GTP-bound state, and induce clustering of late...
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