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Article

Delivering the kiss of death.

Nature immunology - 1 May 2003

Trambas Christina M, Griffiths Gillian M

Abstract excerpt

Cytotoxic T lymphocytes and natural killer cells kill their targets by secreting specialized granules that contain potent cytotoxic molecules. Through the study of rare immunodeficiency diseases in which this granule pathway of killing is impaired, proteins such as Rab27a have been identified as components of the secretory machinery of these killer cells. Recent evidence suggests that the destruction of activated...

Read the complete abstract on PubMed

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Share to Cytoplasmic Granules
Share to Cytotoxicity, Immunologic
Share to Hermanski-Pudlak Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Killer Cells, Natural

Share to rab GTP-Binding Proteins

Share to rab27 GTP-Binding Proteins

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 12719728
DOI: 10.1038/ni0503-399

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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