Article
The effect of peptidoglycan stimulation on basophil-mediated atopic responses during pregnancy and in newborns.
The Journal of asthma : official journal of the Association for the Care of Asthma - 1 May 2011
Yang Ling, Xu Wei-Guo, Xu Yi-Ping, Guo Yin-Shi, Xiong Ying, Shi Gui-Ying
Abstract excerpt
BACKGROUND: Toll-like receptor (TLR) molecules play critical roles in directing the course of atopic diseases by recognizing specific microbial products that activate immune effector cell function. OBJECTIVE: We determined if basophils harvested from neonates genetically predisposed to atopic disease had different levels of TLR2 expression and determined whether putative TLR2 ligands mediated cytokine secretion....
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