Article
Putative regulatory T cells are impaired in cord blood from neonates with hereditary allergy risk.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Mar 2005
Haddeland Unni, Karstensen Anne B, Farkas Lorant, Bø Knut Olav, Pirhonen Jouko, Karlsson Malin, Kvåvik Wenche, Brandtzaeg Per, Nakstad Britt
Abstract excerpt
The hygiene hypothesis implies that the increasing prevalence of allergy in 'westernized' countries is explained by reduced bacterial exposure in early life, but the underlying mechanism remains elusive. We therefore wanted to study the effect of bacterial lipopolysaccharide (LPS) on the generation of regulatory T (T(R)) cells in neonates, and to analyze differences between neonates with allergy risk because of a...
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