Article
Selective development of a strong Th2 cytokine profile in high-risk children who develop atopy: risk factors and regulatory role of IFN-gamma, IL-4 and IL-10.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jul 2001
van der Velden V H, Laan M P, Baert M R, de Waal Malefyt R, Neijens H J, Savelkoul H F
Abstract excerpt
BACKGROUND: The immunological processes in early life and their relation to allergic sensitization leading to a Th2 cytokine profile are still not well understood. OBJECTIVE: To analyse the environmental and genetic risk factors and immunological responses at birth in relation to the development of atopic disease at 12 months of age in a longitudinal study of high-risk children. METHODS: High-risk children were...
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