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Article

Lack of association between toll-like receptor 4 gene polymorphisms and sarcoidosis-related uveitis in Japan.

Molecular vision - 10 Dec 2009

Asukata Yuri, Ota Masao, Meguro Akira, Katsuyama Yoshihiko, Ishihara Mami, Namba Kenichi, Kitaichi Nobuyoshi, Morimoto Shin-Ichiro, Kaburaki Toshikatsu, Ando Yasutaka, Takenaka Shinobu, Inoko Hidetoshi, Ohno Shigeaki, Mizuki Nobuhisa

Abstract excerpt

PURPOSE: Toll-like receptors (TLRs) are pattern-recognition receptors that play an important role in innate and adaptive immune responses to microbial pathogens. Among TLRs, TLR4 recognizes lipopolysaccharides of Gram-negative bacteria. Genetic polymorphisms within the TLR4 gene have been reported to be associated with various inflammatory diseases; therefore, TLR4 appears to be a susceptibility gene for...

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Identifiers

PMID: 20011079
PMCID: PMC2791040

Genes

TLR4

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