Genetic characterization and susceptibility for sarcoidosis in Japanese patients: risk factors of BTNL2 gene polymorphisms and HLA class II alleles.

doi:10.1167/iovs.12-10491

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Article

Genetic characterization and susceptibility for sarcoidosis in Japanese patients: risk factors of BTNL2 gene polymorphisms and HLA class II alleles.

Investigative ophthalmology & visual science - 11 Oct 2012

Suzuki Hitomi, Ota Masao, Meguro Akira, Katsuyama Yoshihiko, Kawagoe Tatukata, Ishihara Mami, Asukata Yuri, Takeuchi Masaki, Ito Norihiko, Shibuya Etsuko, Nomura Eiichi, Uemoto Riyo, Nishide Tadayuki, Namba Kenichi, Kitaichi Nobuyoshi, Morimoto Shin-ichiro, Kaburaki Toshikatsu, Ando Yasutaka, Takenaka Shinobu, Nakamura Jutaro, Saeki Kozou, Ohno Shigeaki, Inoko Hidetoshi, Mizuki Nobuhisa

Abstract excerpt

PURPOSE: Sarcoidosis is a heterogeneous and multisystem granulomatous disorder. The etiology still is uncertain, but the disease currently is thought to be triggered by various genetic as well as environmental factors. Recently, an association between sarcoidosis and the butyrophilin-like 2 (BTNL2) gene located in close proximity to the HLA-DRB1 gene was reported. The purpose of our study was to verify the...

Topics

Adult
Aged
Asian People
Butyrophilins
Case-Control Studies
Female
Genetic Predisposition to Disease
HLA-DQ beta-Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DRB1 Chains

Humans

Japan

Linkage Disequilibrium

Male

Membrane Glycoproteins

Middle Aged

Phenotype

Polymorphism, Single Nucleotide

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 22991420
DOI: 10.1167/iovs.12-10491

Genes

BTNL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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