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Article

Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma

1 Jun 2012

Abstract excerpt

Interactions within the hematopoietic niche in the BM microenvironment are essential for maintenance of the stem cell pool. In addition, this niche is thought to serve as a sanctuary site for malignant progenitors during chemotherapy. Therapy resistance induced by interactions with the BM microenvironment is a major drawback in the treatment of hematologic malignancies and bone-metastasizing solid tumors. To...

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Share to Chemokine receptors and signaling
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PMID: 22653974
DOI: 10.1182/blood-2012-03-414920

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