Targeting the triad: phenotypic plasticity, tumor microenvironment and bone microenvironment in prostate cancer bone-metastatic events.

Abstract excerpt

The incidence and mortality rates of prostate cancer are increasing annually, indicating that it poses a serious threat to men's health. Previous studies have demonstrated that bone-metastatic tumor cells undergo four hallmark bone-metastatic events, including colonization, dormancy, reactivation and bone reconstruction. However, most advanced patients experience four stages of progression and undergo advanced...

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