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The prostate cancer bone marrow niche: more than just ‘fertile soil’

27 Feb 2012

Abstract excerpt

The hematopoietic stem cell (HSC) niche in the bone marrow has been studied extensively over the past few decades, yet the bone marrow microenvironment that supports the growth of metastatic prostate cancer (PCa) has only been recently considered to be a specialized 'niche' as well. New evidence supports the fact that disseminated tumor cells (DTCs) of PCa actually target the HSC niche, displace the occupant HSCs...

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PMID: 22367179
DOI: 10.1038/aja.2011.164

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