Article
Correcting direct effects of ethanol on translation and transcription machinery confers ethanol tolerance in bacteria.
Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2014
Haft Rembrandt J F, Keating David H, Schwaegler Tyler, Schwalbach Michael S, Vinokur Jeffrey, Tremaine Mary, Peters Jason M, Kotlajich Matthew V, Pohlmann Edward L, Ong Irene M, Grass Jeffrey A, Kiley Patricia J, Landick Robert
Abstract excerpt
The molecular mechanisms of ethanol toxicity and tolerance in bacteria, although important for biotechnology and bioenergy applications, remain incompletely understood. Genetic studies have identified potential cellular targets for ethanol and have revealed multiple mechanisms of tolerance, but it remains difficult to separate the direct and indirect effects of ethanol. We used adaptive evolution to generate...
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