Article
High BRAF mutation frequency does not characterize all melanocytic tumor types.
International journal of cancer - 20 Sept 2004
Saldanha Gerald, Purnell David, Fletcher Alan, Potter Linda, Gillies Angela, Pringle J Howard
Abstract excerpt
Cutaneous melanoma (CM) is the most lethal form of skin cancer. Along with some benign melanocytic tumors, the majority shows BRAF or NRAS mutation, but it is not known whether these are essential to all forms of melanocytic neoplasia. We screened 79 melanocytic tumors of different types for BRAF and NRAS mutations and looked at MAPK pathway activity using immunohistochemistry in a subset. Significant differences...
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