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Article

The Role of Protamine 2 Gene Expression and Caspase 9 Activity in Male Infertility

26 Sept 2015

Abstract excerpt

PURPOSE: Approximately 15% of couples are affected by infertility with the man responsible in almost half of the cases. PRMs (protamines) confer a higher order of DNA packaging in sperm than that in somatic cells. Because of the critical roles of PRMs in spermatid differentiation, aberrations in PRM expression or changes in protein structure could be causes of certain types of idiopathic human male infertility....

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PMID: 26392304
DOI: 10.1016/j.juro.2015.08.101

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