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Article

The multifunctional protein nucleophosmin (NPM1) is a human linker histone H1 chaperone.

Biochemistry - 12 Apr 2011

Gadad Shrikanth S, Senapati Parijat, Syed Sajad Hussain, Rajan Roshan Elizabeth, Shandilya Jayasha, Swaminathan Venkatesh, Chatterjee Snehajyoti, Colombo Emanuela, Dimitrov Stefan, Pelicci Pier Giuseppe, Ranga Udaykumar, Kundu Tapas K

Abstract excerpt

Linker histone H1 plays an essential role in chromatin organization. Proper deposition of linker histone H1 as well as its removal is essential for chromatin dynamics and function. Linker histone chaperones perform this important task during chromatin assembly and other DNA-templated phenomena in the cell. Our in vitro data show that the multifunctional histone chaperone NPM1 interacts with linker histone H1...

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Source

Identifiers

PMID: 21425800
DOI: 10.1021/bi101835j

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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