Article
Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy.
Cell death and differentiation - 1 Jul 2014
Auffinger B, Tobias A L, Han Y, Lee G, Guo D, Dey M, Lesniak M S, Ahmed A U
Abstract excerpt
Glioblastoma multiforme patients have a poor prognosis due to therapeutic resistance and tumor relapse. It has been suggested that gliomas are driven by a rare subset of tumor cells known as glioma stem cells (GSCs). This hypothesis states that only a few GSCs are able to divide, differentiate, and initiate a new tumor. It has also been shown that this subpopulation is more resistant to conventional therapies...
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