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Article

Essential roles of telomerase reverse transcriptase hTERT in cancer stemness and metastasis.

FEBS letters - 1 Jun 2018

Hannen Ricarda, Bartsch Jörg W

Abstract excerpt

Maintenance of chromosomal telomere length is a hallmark of cancer cells and a prerequisite for stemness. In 85-90% of all human cancers, telomere length maintenance is achieved by reactivation of telomerase, whereas in the remaining 10-15% cancers, alternative lengthening of telomeres (ALT) is observed. Reactivation of telomerase occurs by various mechanisms, one of which is accumulation of point mutations in...

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Identifiers

PMID: 29749098
DOI: 10.1002/1873-3468.13084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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