Article
Amyloid precursor protein gene (APP) variation in late-onset Alzheimer's disease.
Journal of molecular neuroscience : MN - 1 Sept 2011
Miar Ana, Alvarez Victoria, Corao Ana I, Díaz Marta, Alonso Belén, Martínez Carmen, Calatayud María T, Menéndez Manuel, Morís Germán, Coto Eliecer
Abstract excerpt
Mutations in the beta-amyloid precursor protein gene (APP) have been found in familial early-onset Alzheímer's disease (AD). DNA variants at several genes have been linked to the risk of developing the most common late-onset form of AD (LOAD). A few studies analyzed the contribution of APP variants to LOAD, with negative or conflicting results. We determined the variation in the 18 APP exons and flanking intronic...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Apolipoproteins E
- DNA Mutational Analysis
- Female
- Genetic Predisposition to Disease
- Genotype