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Article

Spontaneous Irs1 passenger mutation linked to a gene-targeted SerpinB2 allele.

Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 2010

Westrick Randal J, Mohlke Karen L, Korepta Lindsey M, Yang Angela Y, Zhu Goujing, Manning Sara L, Winn Mary E, Dougherty Kristiann M, Ginsburg David

Abstract excerpt

In characterizing mice with targeted disruption of the SerpinB2 gene, we observed animals that were small at birth with delayed growth and decreased life expectancy. Although this phenotype cosegregated with homozygosity for the inactive SerpinB2 allele, analysis of homozygous SerpinB2-deficient...

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Source

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Identifiers

PMID: 20837540
DOI: 10.1073/pnas.1012050107
PMCID: PMC2947888

Genes

IRS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20837540-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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