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Article

Serine 16 phosphorylation induces an order-to-disorder transition in monomeric phospholamban.

Biochemistry - 22 Mar 2005

Metcalfe Emily E, Traaseth Nathaniel J, Veglia Gianluigi

Abstract excerpt

Phospholamban (PLB) is a 52 amino acid membrane-endogenous regulator of the sarco(endo)plasmic calcium adenosinetriphosphatase (SERCA) in cardiac muscle. PLB's phosphorylation and dephosphorylation at S16 modulate its regulatory effect on SERCA by an undetermined mechanism. In this paper, we use multidimensional (1)H/(15)N solution NMR methods to establish the structural and dynamics basis for PLB's control of...

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PMID: 15766268
DOI: 10.1021/bi047571e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Serine 16 phosphorylation induces an order-to-disorder transition in monomeric phospholamban.PMID 15766268Read ↗

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