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Article

Protein-protein interactions in calcium transport regulation probed by saturation transfer electron paramagnetic resonance.

Biophysical journal - 19 Sept 2012

James Zachary M, McCaffrey Jesse E, Torgersen Kurt D, Karim Christine B, Thomas David D

Abstract excerpt

We have used electron paramagnetic resonance (EPR) to probe the homo- and heterooligomeric interactions of reconstituted sarcoplasmic reticulum Ca-ATPase (SERCA) and its regulator phospholamban (PLB). SERCA is responsible for restoring calcium to the sarcoplasmic reticulum to allow muscle relaxation, whereas PLB inhibits cardiac SERCA unless phosphorylated at Ser(16). To determine whether changes in protein...

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Identifiers

PMID: 22995510
DOI: 10.1016/j.bpj.2012.08.032
PMCID: PMC3446671

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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