Article
Transmission of single and multiple viral variants in primary HIV-1 subtype C infection.
PloS one - 9 Feb 2011
Novitsky Vladimir, Wang Rui, Margolin Lauren, Baca Jeannie, Rossenkhan Raabya, Moyo Sikhulile, van Widenfelt Erik, Essex M
Abstract excerpt
To address whether sequences of viral gag and env quasispecies collected during the early post-acute period can be utilized to determine multiplicity of transmitted HIV's, recently developed approaches for analysis of viral evolution in acute HIV-1 infection [1,2] were applied. Specifically, phylogenetic reconstruction, inter- and intra-patient distribution of maximum and mean genetic distances, analysis of...
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