Article
Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants.
Journal of virology - 1 Apr 2009
Abrahams M-R, Anderson J A, Giorgi E E, Seoighe C, Mlisana K, Ping L-H, Athreya G S, Treurnicht F K, Keele B F, Wood N, Salazar-Gonzalez J F, Bhattacharya T, Chu H, Hoffman I, Galvin S, Mapanje C, Kazembe P, Thebus R, Fiscus S, Hide W, Cohen M S, Karim S Abdool, Haynes B F, Shaw G M, Hahn B H, Korber B T, Swanstrom R, Williamson C
Abstract excerpt
Identifying the specific genetic characteristics of successfully transmitted variants may prove central to the development of effective vaccine and microbicide interventions. Although human immunodeficiency virus transmission is associated with a population bottleneck, the extent to which different factors influence the diversity of transmitted viruses is unclear. We estimate here the number of transmitted...
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