Article
High Multiplicity Infection by HIV-1 in Men Who Have Sex with Men.
PLoS pathogens - 13 May 2010
Li Hui, Bar Katharine J, Wang Shuyi, Decker Julie M, Chen Yalu, Sun Chuanxi, Salazar-Gonzalez Jesus F, Salazar Maria G, Learn Gerald H, Morgan Charity J, Schumacher Joseph E, Hraber Peter, Giorgi Elena E, Bhattacharya Tanmoy, Korber Bette T, Perelson Alan S, Eron Joseph J, Cohen Myron S, Hicks Charles B, Haynes Barton F, Markowitz Martin, Keele Brandon F, Hahn Beatrice H, Shaw George M
Abstract excerpt
Elucidating virus-host interactions responsible for HIV-1 transmission is important for advancing HIV-1 prevention strategies. To this end, single genome amplification (SGA) and sequencing of HIV-1 within the context of a model of random virus evolution has made possible for the first time an unambiguous identification of transmitted/founder viruses and a precise estimation of their numbers. Here, we applied this...
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