Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapid identification of the hepatic cytochrome P450 2C19 activity using a novel and noninvasive [13C]pantoprazole breath test.

The Journal of pharmacology and experimental therapeutics - 1 Apr 2009

Desta Zeruesenay, Modak Anil, Nguyen Phuong D, Lemler Suzanne M, Kurogi Yasuhisa, Li Lang, Flockhart David A

Abstract excerpt

We tested the hypothesis that the stable isotope [(13)C]pantoprazole is O-demethylated by cytochrome P450 CYP2C19 and that the (13)CO(2) produced and exhaled in breath as a result can serve as a safe, rapid, and noninvasive phenotyping marker of CYP2C19 activity in vivo. Healthy volunteers who had been genotyped for the CYP2C19(*)2, CYP2C19(*)3, and CYP2C19(*)17 alleles were administered a single oral dose of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 2-Pyridinylmethylsulfinylbenzimidazoles
Share to Aryl Hydrocarbon Hydroxylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breath Tests

Share to Carbon Dioxide

Share to Cytochrome P-450 CYP2C19

Share to Enzyme Inhibitors

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 19136640
DOI: 10.1124/jpet.108.147751
PMCID: PMC2670589

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapid identification of the hepatic cytochrome P450 2C19 activity using a novel and noninvasive [13C]pantoprazole breath test.PMID 19136640Read ↗

Is (+)-[13C]-pantoprazole better than (±)-[13C]-pantoprazole for the breath test to evaluate CYP2C19 enzyme activity?Semantic proximity Read ↗

Stereoselective pharmacokinetics of stable isotope (+/-)-[13C]-pantoprazole: Implications for a rapid screening phenotype test of CYP2C19 activity.Semantic proximity Read ↗

Utility of the 13 C-pantoprazole breath test as a CYP2C19 phenotyping probe for children.Semantic proximity Read ↗

Prediction of clopidogrel low responders by a rapid CYP2C19 activity test.Semantic proximity Read ↗

[13C]pantoprazole breath test as a predictor of the anti-platelet function of clopidogrel.Semantic proximity Read ↗

Stable isotope biomarker breath tests for human metabolic and infectious diseases: a review of recent patent literature.Semantic proximity Read ↗

PBPK modeling to predict the pharmacokinetics of pantoprazole in different CYP2C19 genotypes.Semantic proximity Read ↗

Evaluation of a [13C]-dextromethorphan breath test to assess CYP2D6 phenotype.Semantic proximity Read ↗

CYP2C19 genotype and phenotype determined with omeprazole in patients with acid-related disorders with and without Helicobacter pylori infection.Semantic proximity Read ↗

Application of Microdosed Intravenous Omeprazole to Determine Hepatic CYP2C19 Activity.Semantic proximity Read ↗

CYP2C19 polymorphism affects single-dose pharmacokinetics of oral pantoprazole in healthy volunteers.Semantic proximity Read ↗

13C-caffeine breath test identifies single nucleotide polymorphisms associated with caffeine metabolism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.