Article
[13C]pantoprazole breath test as a predictor of the anti-platelet function of clopidogrel.
European journal of clinical pharmacology - 1 May 2010
Furuta Takahisa, Iwaki Takayuki, Umemura Kazuo
Abstract excerpt
BACKGROUNDS/AIMS: Clopidogrel, a platelet inhibitor, is metabolized by cytochrome P450 2C19 (CYP2C19) to its active metabolite and, consequently, its anti-platelet efficacy is influenced by CYP2C19 activity. The aim of this study was to determine whether the [(13)C]pantoprazole breath test, a recently developed tool used to measure CYP2C19 activity, can predict the anti-platelet efficacy of clopidogrel. METHODS:...
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