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[Comparative effectiveness of the antisecretory action of rabeprazole and esomeprazole in people with rapid metabolism of proton pump inhibitors].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology - 1 Jan 2003

Morozov S V, Tsodikova O M, Isakov V A, Gushchin A E, Shipulin G A

Abstract excerpt

AIM: To compare antisecretory effects of Rabeprazole and Esomeprazole in proton pump inhibitors extensive metabolizers in an open, randomized, two-way crossover study. METHODS: Sixteen GERD H. pylori-positive patients (8 men, mean age 49.6 and 8 women, mean age 49.3) with the homozygous extensive metabolizer genotype of CYP2C19 determined by polymerase chain reaction-restriction fragment length polymorphism...

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PMID: 15065530

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