Article
Common variants in PARK loci and related genes and Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 1 Feb 2011
Chung Sun Ju, Armasu Sebastian M, Biernacka Joanna M, Lesnick Timothy G, Rider David N, Lincoln Sarah J, Ortolaza Alexandra I, Farrer Matthew J, Cunningham Julie M, Rocca Walter A, Maraganore Demetrius M
Abstract excerpt
Rare mutations in PARK loci genes cause Parkinson's disease (PD) in some families and isolated populations. We investigated the association of common variants in PARK loci and related genes with PD susceptibility and age at onset in an outbred population. A total of 1,103 PD cases from the upper Midwest, USA, were individually matched to unaffected siblings (n = 654) or unrelated controls (n = 449) from the same...
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