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Article

Establishing the role of rare coding variants in known Parkinson's disease risk loci.

Neurobiology of aging - 1 Nov 2017

Jansen Iris E, Gibbs J Raphael, Nalls Mike A, Price T Ryan, Lubbe Steven, van Rooij Jeroen, Uitterlinden André G, Kraaij Robert, Williams Nigel M, Brice Alexis, Hardy John, Wood Nicholas W, Morris Huw R, Gasser Thomas, Singleton Andrew B, Heutink Peter, Sharma Manu

Abstract excerpt

Many common genetic factors have been identified to contribute to Parkinson's disease (PD) susceptibility, improving our understanding of the related underlying biological mechanisms. The involvement of rarer variants in these loci has been poorly studied. Using International Parkinson's Disease Genomics Consortium data sets, we performed a comprehensive study to determine the impact of rare variants in 23...

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Identifiers

PMID: 28867149
DOI: 10.1016/j.neurobiolaging.2017.07.009
PMCID: PMC8722270

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SPATA19
STBD1

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