Article
Massive expression of germ cell-specific genes is a hallmark of cancer and a potential target for novel treatment development
15 Jun 2018
Abstract excerpt
Cancer cells have been found to frequently express genes that are normally restricted to the testis, often referred to as cancer/testis (CT) antigens or genes. Because germ cell-specific antigens are not recognized as "self" by the innate immune system, CT-genes have previously been suggested as ideal candidate targets for cancer therapy. The use of CT-genes in cancer therapy has thus far been unsuccessful, most...
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