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Article

On the Origin of Testicular Germ Cell Tumors: From Gonocytes to Testicular Cancer

6 Jun 2019

Abstract excerpt

Human primordial germ cells (PGCs) have been described in the yolk sac wall around the beginning of the third week. From week 4 to 5, they migrate under control of SCF/c-KIT signaling pathway to the genital ridge, where they become gonocytes. PGCs and gonocytes express classic pluripotency markers, such as KIT, NANOG and OCT3/4 that, during spermatogonia differentiation, are gradually suppressed, and substituted...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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Identifiers

PMID: 31244770
DOI: 10.3389/fendo.2019.00343

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