Article
Genetic variation in UGT1A1 typical of Gilbert syndrome is associated with unconjugated hyperbilirubinemia in patients receiving tocilizumab.
Pharmacogenetics and genomics - 1 Jul 2011
Lee Janet S, Wang Jianmei, Martin Mitchell, Germer Soren, Kenwright Andrew, Benayed Ryma, Spleiss Olivia, Platt Adam, Pilson Robert, Hemmings Andrew, Weinblatt Michael E, Kaplowitz Neil, Krasnow Joel
Abstract excerpt
OBJECTIVE: Tocilizumab, a monoclonal antibody to interleukin-6 receptor, was recently approved for the treatment of moderate-to-severe rheumatoid arthritis. Two patients during clinical development met laboratory, but not clinical, criteria for Hy's law with bilirubin elevations suspected as a result of genetic variation in uridine diphosphoglucose glucuronosyltransferase (UGT1A1) typical of Gilbert syndrome....
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