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Article

A Gilbert's syndrome UGT1A1 variant confers susceptibility to tranilast-induced hyperbilirubinemia.

The pharmacogenomics journal - 1 Jan 2004

Danoff T M, Campbell D A, McCarthy L C, Lewis K F, Repasch M H, Saunders A M, Spurr N K, Purvis I J, Roses A D, Xu C-F

Abstract excerpt

Tranilast (N-(3'4'-demethoxycinnamoyl)-anthranilic acid (N-5)) is an investigational drug for the prevention of restenosis following percutaneous transluminal coronary revascularization. An increase in bilirubin levels was observed in 12% of patients upon administration of tranilast in a phase II...

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Source

Identifiers

PMID: 14647407
DOI: 10.1038/sj.tpj.6500221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14647407-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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