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Article

Clinical significance of genetic variations in the PI3K/PTEN/AKT/mTOR pathway in Korean patients with colorectal cancer.

Oncology - 1 Jan 2010

Kim Jong Gwang, Chae Yee Soo, Sohn Sang Kyun, Kang Byung Woog, Moon Joon Ho, Lee Soo Jung, Jeon Seong Woo, Park Jun Seok, Park Jin Young, Choi Gyu Seog

Abstract excerpt

OBJECTIVE: Signaling through the PI3K/PTEN/AKT/mTOR pathway is responsible for balancing cell survival and apoptosis. Accordingly, the present study analyzed 14 SNPs of the PI3K/PTEN/AKT/mTOR pathway genes and their impact on the prognosis for patients with colorectal cancer. METHODS: 444 consecutive patients with surgically resected colorectal adenocarcinoma were enrolled in the present study. The genomic DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphatidylinositol 3-Kinases

Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

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Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 21412012
DOI: 10.1159/000320761

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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