Article
Phospholipase C-β3 is a key modulator of IL-8 expression in cystic fibrosis bronchial epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2011
Bezzerri Valentino, d'Adamo Pio, Rimessi Alessandro, Lanzara Carmen, Crovella Sergio, Nicolis Elena, Tamanini Anna, Athanasakis Emmanouil, Tebon Maela, Bisoffi Giulia, Drumm Mitchell L, Knowles Michael R, Pinton Paolo, Gasparini Paolo, Berton Giorgio, Cabrini Giulio
Abstract excerpt
Respiratory insufficiency is the major cause of morbidity and mortality in patients affected by cystic fibrosis (CF). An excessive neutrophilic inflammation, mainly orchestrated by the release of IL-8 from bronchial epithelial cells and amplified by chronic bacterial infection with Pseudomonas aeruginosa, leads to progressive tissue destruction. The anti-inflammatory drugs presently used in CF patients have...
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