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Article

PLCB3 Loss of Function Reduces Pseudomonas aeruginosa-Dependent IL-8 Release in Cystic Fibrosis.

American journal of respiratory cell and molecular biology - 1 Oct 2018

Rimessi Alessandro, Bezzerri Valentino, Salvatori Francesca, Tamanini Anna, Nigro Federica, Dechecchi Maria Cristina, Santangelo Alessandra, Prandini Paola, Munari Silvia, Provezza Lisa, Garreau de Loubresse Nicolas, Muller Jean, Ribeiro Carla M P, Lippi Giuseppe, Gambari Roberto, Pinton Paolo, Cabrini Giulio

Abstract excerpt

The lungs of patients with cystic fibrosis (CF) are characterized by an exaggerated inflammation driven by secretion of IL-8 from bronchial epithelial cells and worsened by Pseudomonas aeruginosa infection. To identify novel antiinflammatory molecular targets, we previously performed a genetic study of 135 genes of the immune response, which identified the c.2534C>T (p.S845L) variant of phospholipase C-β3 (PLCB3)...

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Identifiers

PMID: 29668297
DOI: 10.1165/rcmb.2017-0267OC

Genes

PLCB3

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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