Article
Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families.
Genes and immunity - 1 Jan 2006
Barnes K C, Grant A V, Baltadzhieva D, Zhang S, Berg T, Shao L, Zambelli-Weiner A, Anderson W, Nelsen A, Pillai S, Yarnall D P, Dienger K, Ingersoll R G, Scott A F, Fallin M D, Mathias R A, Beaty T H, Garcia J G N, Wills-Karp M
Abstract excerpt
Proinflammatory and immunoregulatory products from C3 play a major role in phagocytosis, respiratory burst, and airways inflammation. C3 is critical in adaptive immunity; studies in mice deficient in C3 demonstrate that features of asthma are significantly attenuated in the absence of C3. To test the hypothesis that the C3 gene on chromosome 19p13.3-p13.2 contains variants associated with asthma and related...
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