Article
Genetic relationships between systemic lupus erythematosus and a positive antinuclear antibody test in the absence of autoimmune disease.
Lupus science & medicine - 12 Jun 2025
Khan Atlas, Karakoc Gul, Liu Ge, Zanussi Jacy, Olsen Nancy J, Shi Mingjian, Cox Nancy J, Mosley Jonathan, Stein Charles Michael, Kiryluk Krysztof, Wei Wei-Qi, Mentch Frank, Hebbring Scott, Linneman James, Kawai Vivian
Abstract excerpt
OBJECTIVE: We defined the genetic factors associated with a positive ANA test (ANA+) in the absence of autoimmune disease and tested the association with SLE. METHODS: Using a case-control design, we performed a genome-wide association study (GWAS) in individuals of European ancestry without an autoimmune disease who had ANA tested as part of clinical care from DNA biobanks linked to de-identified electronic...
Read the complete abstract on PubMedTopics
- Humans
- Lupus Erythematosus, Systemic
- Genome-Wide Association Study
- Polymorphism, Single Nucleotide