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International Consensus Definition of DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia

2 Nov 2020

Abstract excerpt

PURPOSE: Known clinical and genetic markers have limitations in predicting disease course and outcome in juvenile myelomonocytic leukemia (JMML). DNA methylation patterns in JMML have correlated with outcome across multiple studies, suggesting it as a biomarker to improve patient stratification. However, standardized approaches to classify JMML on the basis of DNA methylation patterns are lacking. We, therefore,...

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PMID: 33139265
DOI: 10.1158/1078-0432.ccr-20-3184

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