Article

Stabilization of H5 highly pathogenic avian influenza hemagglutinin improves vaccine-elicited neutralizing antibody responses

2025-08-02

Abstract excerpt

Transmission of highly pathogenic avian influenza from H5 clade 2.3.4.4b has expanded in recent years to infect large populations of birds and mammals, heightening the risk of a human pandemic. Influenza viruses adapted to transmission in birds and some other animals tend to have a less stable hemagglutinin (HA) than seasonal influenza viruses, enabling membrane fusion at comparatively high pH levels. Here, we com...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0779a927-f7e2-5b9b-ab22-b1453e25fd8a
DOI: 10.1101/2025.07.30.667762

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Stabilization of H5 highly pathogenic avian influenza hemagglutinin improves vaccine-elicited neutralizing antibody responsesDOI 10.1101/2025.07.30.667762Read

Stabilization of the H5 clade 2.3.4.4b hemagglutinin improves vaccine-elicited neutralizing antibody responses in mice.Semantic proximity Read

Identification of Stabilizing Mutations in an H5 Hemagglutinin Influenza Virus ProteinSemantic proximity Read

A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccineSemantic proximity Read

Identification and Structural Characterization of a Broadly Neutralizing Antibody Targeting a Novel Conserved Epitope on the Influenza Virus H5N1 HemagglutininSemantic proximity Read

Key Amino Acid Residues That Determine the Antigenic Properties of Highly Pathogenic H5 Influenza Viruses Bearing the Clade 2.3.4.4 Hemagglutinin GeneSemantic proximity Read

Identification of thermostability-enhancing mutations in H9N2 avian influenza virus hemagglutinin.Semantic proximity Read

Conserved sites on the influenza H1 and H3 hemagglutinin recognized by human antibodiesSemantic proximity Read

Large-Scale Computational Modeling of H5 Influenza Variants Against HA1-Neutralizing AntibodiesSemantic proximity Read

Structural insights into the broad protection against H1 influenza viruses by a computationally optimized hemagglutinin vaccineSemantic proximity Read

N-linked glycosylation enhances hemagglutinin stability in avian H5N6 influenza virus to promote adaptation in mammalsSemantic proximity Read

Stabilized Full-Length Measles Fusion Protein Elicits Potent Immunity and Protection In VivoSemantic proximity Read