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Article

Immune Escape Adaptive Mutations in the H7N9 Avian Influenza Hemagglutinin Protein Increase Virus Replication Fitness and Decrease Pandemic Potential.

Journal of virology - 15 Sept 2020

Chang Pengxiang, Sealy Joshua E, Sadeyen Jean-Remy, Bhat Sushant, Lukosaityte Deimante, Sun Yipeng, Iqbal Munir

Abstract excerpt

H7N9 avian influenza viruses (AIVs) continue to evolve and remain a huge threat to human health and the poultry industry. Previously, serially passaging the H7N9 A/Anhui/1/2013 virus in the presence of homologous ferret antiserum resulted in immune escape viruses containing amino acid substitutions alanine to threonine at residues 125 (A125T) and 151 (A151T) and leucine to glutamine at residue 217 (L217Q) in the...

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Identifiers

PMID: 32699084
DOI: 10.1128/JVI.00216-20
PMCID: PMC7495387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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