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Article

Elevated Transcript Levels From the MDM2 P1 Promoter and Low p53 Transcript Levels Are Associated With Poor Prognosis in Human Pancreatic Ductal Adenocarcinoma

8 Dec 2010

Abstract excerpt

UNLABELLED: OBJECTDIVES: Mouse double minute 2 is a key negative regulator of the p53 protein, a central node in the mediation of tumor suppression. The MDM2 gene contains 2 differently regulated promoters, MDM2-P1 and MDM2-P2, which differ strongly in their biological and clinical importance. METHODS: We assess the clinical significance of the expression of messenger RNA (mRNA) transcripts originating from both...

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PMID: 21404460
DOI: 10.1097/mpa.0b013e3181f95104

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