Article
Amplification of Mdmx and overexpression of MDM2 contribute to mammary carcinogenesis by substituting for p53 mutations.
Diagnostic pathology - 25 Mar 2014
Yu Qiong, Li Yan, Mu Kun, Li Zhishuang, Meng Qingyong, Wu Xiaojuan, Wang Yan, Li Li
Abstract excerpt
BACKGROUND: The p53 tumor suppressor gene is mutated or deleted in nearly half of human cancers. The murine double minute 2 (Mdm2) and Mdmx represent two important cellular regulators of p53. The aim of this study was to evaluate the abnormalities of p53, Mdmx and Mdm2 genes in archived breast cancers. METHODS: We assessed the genetic instability at p53, Mdmx and Mdm2 using high resolution multi-color fluorescent...
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