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Article

Association of HDM2 transcript levels with age of onset and prognosis in soft tissue sarcomas.

Molecular cancer research : MCR - 1 Oct 2008

Taubert Helge, Bartel Frank, Greither Thomas, Bache Matthias, Kappler Matthias, Köhler Thomas, Böhnke Anja, Lautenschläger Christine, Schmidt Hannelore, Holzhausen Hans-Jürgen, Hauptmann Steffen, Würl Peter

Abstract excerpt

The p53 stress response is crucial for the prevention of tumor formation. The oncogene HDM2 is one of the key negative regulators of p53 and is a central node in the p53 pathway. P53 and HDM2 form an oscillating feedback loop. HDM2 expression is regulated by different promoters. To evaluate its c...

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Identifiers

PMID: 18922973
DOI: 10.1158/1541-7786.MCR-07-2150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18922973-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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