Article
Mutations of p53 and K-ras correlate TF expression in human colorectal carcinomas: TF downregulation as a marker of poor prognosis.
International journal of colorectal disease - 1 May 2011
Rao Benqiang, Gao Yuanhong, Huang Jun, Gao Xiaoyan, Fu Xinhui, Huang Meijin, Yao Jiayin, Wang Jingping, Li Wanglin, Zhang Junxiao, Liu Huanliang, Wang Lei, Wang Jianping
Abstract excerpt
BACKGROUND: Tissue factor (TF) is emphasized as the promising target in the future targeted therapy strategy for colorectal cancer (CRC). Recent evidence showed that TF expression is under the control of K-ras and p53. However, a comprehensive evaluation of TF expression, K-ras status, and p53 mutation has not been systematically analyzed. The aims of this study were to identify the percentages of positive TF in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.